Azoospermia treatment / Top clinic in Germany, Friedrichshafen

Azoospermia treatment

The andrological department at the clinic of Friedrichshafen, led by M.D. Claus F. Fieseler, offers modern methods of male infertility treatment. One oft he most frequent cause of childlessness is azoospermia. Azoospermia is a pathological condition, which is characterized with lack of vital sperm in the ejaculate. Healthy male ejaculate has more than twenty million mature sperm per millimeter (semen concentration), with at least half the sperm having normal sperm motility and sperm morphology features (appearance, shape). Azoospermia is characterized with deviation in respect to the three criteria: semen concentration, sperm mobility, semen morphology.

Generally the specialists differentiate between a temporary and permanent azoospermia. Being the number 1 cause of male infertility, azoospermia can be attributed to various physiological disorders. Spermatogenesis (sperm production) may be affected with the overheating of the testes (e.g. due to tight-fitting underwear). The consumption of drugs (cimetidine), alcohol, nicotine and the exposure to toxic substances (such as pesticides) can also adversely affect the sperm quality.

In case of obstructive azoospermia the normal amount of sperm is produced, and an obstruction (usually at the level of the epididymis) does not allow them to get out. Obstruction may occur due to congenital abnormalities, or inflammation, injury and surgery of the reproductive system.

Diagnosis of azoospermia

Before the treatment of azoospermia the comprehensive diagnosis should be performed. The German experts conduct the following procedures and examinations:

  • examination of the patient, during which the doctor pays attention to the physical condition, the size and shape of the genitals. Besides there usually occur palpation of the scrotum, examination the testicles and their appendages etc.;
  • study of the patient's anamnesis, which is very important in the treatment of azoospermia (experienced diseases, inflammation of the urogenital system, trauma, surgery, living conditions, potential exposure and toxic effects);
  • blood test men (biochemical, clinical, as well as determining the level of hormones);
  • urin test after ejaculation for determining the presence of sperm in it and, as a consequence, the identification of the seminiferous tract obstruction;
  • semen analysis to determine sperm, their quantity and quality.

Semen analysis

Prior to any azoospermia treatment a semen analysis should be performed. At the Clinic of Friedrichshafen the semen examination is usually carried out with computer assistance (microscopically) using an image analysis program. The specialists determine such parameters as: motility, the concentration (number of sperm per milliliter) and morphology of the spermatozoa. Furthermore, they evaluate the occurrence of erythrocytes (red blood cells), leukocytes (white blood cells) and bacteria. A so-called azoospermia implies that there are no sperm in ejaculate. These very serious diagnosis should be made only if it has been repeatedly confirmed by 2-3 spermiograms.

Is it possible to treat azoospermia?

The outcome of azoospermia treatment depends on the form of the disease. Our professional team will help to diagnose azoospermia, to decide how to treat it and will tell you the forecasts.

If the causes of azoospermia can be eliminated, for example, in case of obstruction or varicocele, azoospermia is treated surgically. Usually after the surgical treatment of azoospermia the disease symptoms disappear quickly and the patient can become a father. Endocrine disorders that lead to the secretion of azoospermia can be corrected with the help of modern hormaone preparates.

If the secretory azoospermia occurs due to hypogonadism, treatment begins with a stimulating therapy with gonadotropins (hormones secreted by the pituitary which stimulate the activity of the gonads). Such treatment results in the appearance of sperm in the ejaculate and spontaneous pregnancy.

In case the treatment proved to be inefficient, the patient is included in the program of assisted reproductive technologies. The best method of obtaining semen with secretory azoospermia is a bilateral multifocal biopsy of the testicles. According to recent clinical studies, even in case of hypergonadotropic hypogonadism up to 65% of vital spermatozoa can be obtained.

Getting sperm for IVF cycle

Azoospermia treatment in Germany depends on the species and the reasons that have led to the disease. In mild form of the disease medical treatment of azoospermia can be efficient: the course of antibiotics or hormonal therapy are efficient in 40% of all cases of azoospermia treatment.

A more difficult issue is the infertility treatment of patients with non-obstructive forms of infertility. The best way to obtain sperm in case nonobstructive azoospermia is a bilateral multifocal testicular biopsy. There are several efficient ways to get sperm in case of azoospermia:

  • MESA (microsurgical epididymal sperm aspiration). MESA stands for surgical extraction of sperm from the epididymal tubules. This procedure is done in direct cooperation with our IVF laboratory. The success of the operation is checked directly, the sperm obtained can be processed immediately and optionally frozen.
  • TESA: Testicular sperm extraction refers to the extraction of sperm from individual pieces of tissue of the testis. If a testicular biopsy must be performed, it should therefore always be additionally combined with a TESE. The TESE is then applied in the majority of cases of azoospermia.

If you are interested in diagnosis or treatment of male infertility in Germany, please don’t hesitate to apply for the free phone consultation of the andrology specialist at the Clinic of Friedrichshafen.

Azoospermia treatment

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Comments and questions

MH 2020-10-25 / 14:50

My husband was diagnosed to have Azospermia. We look for treatment to have children. We live already in Germany. How to book a Consultation?

RV 2019-04-29 / 08:38

Hi, I am 41 years old male diagnosed with azoospermia (sertoli cell only syndrome) 2 years ago. My karyotype was normal and no AZF microdeletions were found in the genetic study. My FSH is fluctuating between 23-32 mIU/mL. My AMH is 3.82 ng/mL (normal range in males - 0.77-14.5 ng/mL). Can my condition be treated or reverted?

IS 2018-07-23 / 18:32

I wish to enquire about treatment of azospermia with stem cells. The patient can come to germany but we were unable to find the address. Can you please help so we can arrange for the patient to travel.
Thank you.

TL 2018-06-02 / 19:20

We are looking for stem cell therapy for Azoospermia is there any way to cure with?

MO 2017-11-11 / 06:49

I would like to ask about stem cell therapy for azoospermia treatment,
Does it offer in your clinic?

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Medical Staff

MD PD H.-W. Vollert

MD PD H.-W. Vollert
Head of the Gynaecology Department

MD Bernd König

MD Bernd König
Head physician assistant

MD Ina Seidenspinner

MD Ina Seidenspinner
Senior physician

MD Karin Roth

MD Karin Roth
Senior physician

MD Alexandru Armion

MD Alexandru Armion
Senior physician

Daniela Reichert

Daniela Reichert
Medical secretary


IVF treatment



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